Key result
The O3039 vaccine strain, alone or combined with O1 Manisa, protected cattle against the O/ME-SA/Ind/2001d lineage of FMD virus from clinical disease even at 7 days post-vaccination.
Why the study?
Emerging O/ME-SA/Ind-2001 lineage viruses showed poor in vitro matching and less challenge protection with the widely used O1 Manisa vaccine strain, requiring evaluation of alternative vaccine strains.
Population
Cattle
Comparison
O3039 vaccine strain alone or combined with O1 Manisa followed by heterologous challenge
Authors
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Updated strain matching remains essential for FMD control; leaves open optimal adjuvant and antigen selection for emerging variants.
The O3039 vaccine strain, alone or with O1 Manisa, provides effective emergency protection in cattle against the emergent O/ME-SA/Ind-2001d FMD virus lineage.
Singanallur et al. (2021) studied Foot-and-mouth disease (FMD). O3039 vaccine strain alone or combined with O1 Manisa vs. O1 Manisa vaccine strain was evaluated on Protection from clinical disease, reduction in viraemia and virus excretion. The O3039 vaccine strain, alone or combined with O1 Manisa, protected cattle against the O/ME-SA/Ind/2001d lineage of FMD virus from clinical disease even at 7 days post-vaccination.
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