Key result
The O3039 vaccine strain, alone or combined with O1 Manisa, effectively protected cattle against the O/ME-SA/Ind/2001d FMD virus lineage at 7 and 21 days post-vaccination.
Why the study?
The emerging O/ME-SA/Ind-2001 lineage of foot-and-mouth disease virus showed a poor match with the widely used O1 Manisa vaccine strain, requiring evaluation of alternative vaccine strains.
Does the O3039 vaccine strain protect cattle against heterologous challenge with the O/ME-SA/Ind2001d FMD virus lineage?
Population
Cattle challenged with an O/ME-SA/Ind-2001d sub-lineage virus
Comparison
O3039 vaccine strain alone or in combination with O1 Manisa
Follow-up
7 days and 21 days post-vaccination
Authors
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Limited FMD vaccine strains restrict outbreak control; leaves open rapid efficacy testing against emerging variants.
Does the O3039 vaccine strain protect cattle against heterologous challenge with the O/ME-SA/Ind2001d FMD virus lineage?
The O3039 FMD vaccine strain provides effective emergency protection in cattle against the emerging O/ME-SA/Ind-2001d lineage.
Nagendrakumar B. Singanallur (2021) studied Foot-and-mouth disease (FMD). O3039 vaccine strain alone or in combination with O1 Manisa vaccine strain was evaluated on Protection from clinical disease, reduction in viraemia and virus excretion. The O3039 vaccine strain, alone or combined with O1 Manisa, effectively protected cattle against the O/ME-SA/Ind/2001d FMD virus lineage at 7 and 21 days post-vaccination.
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