Key result
The peak VO2 and VE/VCO2 slope cut-offs identifying a 20% 10-year risk of cardiovascular death, urgent transplant, or LVAD in heart failure patients progressively decreased and increased over time.
Why the study?
It was unknown how prognostic thresholds of peak VO2 and VE/VCO2 slope have changed over the last 20 years alongside improvements in HF prognosis.
Population
6083 HF patients enrolled in the MECKI score database between 1993 and 2015
Comparison
Four enrolment periods (1993-2000 vs 2001-2005 vs 2006-2010 vs 2011-2015)
Design
Retrospective cohort study
Follow-up
10 years
Authors
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The prognostic thresholds for peak VO2 and VE/VCO2 slope in heart failure have significantly shifted over the last 20 years due to overall improvements in patient survival, indicating that historical cut-offs must be updated.
Cohort (n=6,083)
Yes
The prognostic thresholds for peak VO2 and VE/VCO2 slope in heart failure have significantly shifted over the last 20 years due to overall improvements in patient survival, indicating that historical cut-offs must be updated.
Paolillo et al. (2019) conducted a cohort in Heart failure (n=6,083). Time period of enrolment (1993-2015) vs. Earlier time periods was evaluated on 10-year overall risk (cardiovascular death, urgent heart transplantation, or left ventricular assist device implantation). The peak VO2 and VE/VCO2 slope cut-offs identifying a 20% 10-year risk of cardiovascular death, urgent transplant, or LVAD in heart failure patients progressively decreased and increased over time.
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