Key result
Diabetic patients presenting with NSTEMI had significantly more severe coronary artery disease compared to non-diabetics, indicated by a higher mean Gensini score (71.18 vs 59.84) and greater prevalence of multivessel disease (80.2% vs 59.3%).
Why the study?
Diabetic patients are at increased risk of coronary artery disease, but the extent and severity of disease in patients presenting with NSTEMI with versus without diabetes needed comparison.
Does the presence of diabetes mellitus increase the extent and severity of coronary artery disease in patients presenting with NSTEMI?
Cross-Sectional (n=172)
No
Does the presence of diabetes mellitus increase the extent and severity of coronary artery disease in patients presenting with NSTEMI?
Absolute Event Rate: 71.18% vs 59.84%
p-value: p=0.04
In patients presenting with NSTEMI, the presence of diabetes mellitus is associated with significantly more extensive and severe coronary artery disease on angiography.
Diabetes associated with more extensive CAD in NSTEMI; leaves open whether this alters risk stratification or revascularization thresholds.
Background and Aims: Diabetic patients are at increased risk of developing coronary artery disease. This study was conducted with the aim to compare the extent and severity of coronary artery disease in patients with and without diabetes presenting with non ST segment elevation myocardial infarction (NSTEMI). Methods: This was a single center, hospital based, cross sectional, observational comparative study in which total 172 patients presenting with NSTEMI were divided into two groups of 86 patients each based on presence or absence of diabetes mellitus. Demographic, laboratory and angiographic data were analysed and compared between two groups. Results: Among 86 patients enrolled in each group demographic characteristics and risk profile were not significantly different except for smoking status. Significant number of non-diabetics were current smoker (26.7% vs. 9.3%; p < 0.01). Hypertension was the most common risk factor in both groups. Non-diabetic patients had significantly high single vessel disease when compared to diabetics (11.6% vs 24.4%; p=0.03) while multivessel disease was significantly higher among diabetics (80.2% vs 59.3%; p<0.01). Diabetics had severe coronary artery disease with significantly high Gensini score (71.18±39.03 vs 59.84±33.68; p=0.04). There was no difference in terms of type of vessel affected. Conclusions: Diabetic patients presenting with NSTEMI are likely to have more severe and extensive coronary artery disease compared to non-diabetic patients.
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Timalsena et al. (2020) conducted a cross-sectional in Non-ST-Segment Elevation Myocardial Infarction (NSTEMI) (n=172). Diabetes Mellitus vs. Without Diabetes Mellitus was evaluated on Gensini score (severity of coronary artery disease) (p=0.04). Diabetic patients presenting with NSTEMI had significantly more severe coronary artery disease compared to non-diabetics, indicated by a higher mean Gensini score (71.18 vs 59.84) and greater prevalence of multivessel disease (80.2% vs 59.3%).
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