Key result
Sequential biventricular pacing optimized cardiac output by augmenting right ventricular contractility, which was maximized with RV-first pacing during acute right ventricular pressure overload.
Why the study?
Does sequential biventricular pacing improve cardiac output and right ventricular contractility during acute right ventricular pressure overload in a porcine model?
Population
6 anesthetized, open-chest pigs
Comparison
Sequential biventricular pacing (BiVP) vs Control state vs acute right ventricular…
Design
Preclinical
Authors
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Does not support clinical use; hypothesis-generating for sequential BiV pacing in acute RV overload.
Does sequential biventricular pacing improve cardiac output and right ventricular contractility during acute right ventricular pressure overload in a porcine model?
p-value: p=0.007
Sequential biventricular pacing optimization improves cardiac output by augmenting right ventricular contractility through changes in mechanical interventricular synchrony during acute right ventricular pressure overload.
Quinn et al. (2006) studied acute right ventricular pressure overload (n=6). sequential biventricular pacing (BiVP) vs. control state was evaluated on cardiac output and ventricular contractility (dP/dt(max)) (p=0.007). Sequential biventricular pacing optimized cardiac output by augmenting right ventricular contractility, which was maximized with RV-first pacing during acute right ventricular pressure overload.
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