What question did this study set out to answer?

This study aims to examine gender differences in endothelial function among adolescent patients with type 1 diabetes.

May 1, 2006Congenital Heart Disease

Altered Endothelial Function in Asymptomatic Male Adolescents with Type 1 Diabetes

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Why the study?

Is endothelial dysfunction present in asymptomatic adolescents with type 1 diabetes compared to healthy controls?

Population

40 adolescents aged 12-16 years, comprising 20 with type 1 diabetes and 20 age- and gender-matched…

Design

Case-control

Authors

FMFarid H. MahmudSickKids Foundation MEMicheal G. Earing RLRobert A. LeeMayo Clinic in Arizona

Discussion

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Implication

Endothelial dysfunction may be gender-specific in asymptomatic adolescents with type 1 diabetes; hypothesis-generating and requires prospective confirmation before clinical consideration.

Key Points

This study aims to examine gender differences in endothelial function among adolescent patients with type 1 diabetes.
Measured endothelial function using reactive hyperemia-peripheral arterial tonometry in 20 diabetic subjects and 20 matched controls aged 12-16.
Excluded confounding factors like smoking, obesity, and hypertension.
Assessed metabolic control and lipid profiles of both diabetic and control groups.
Male diabetic subjects had lower RH-PAT values than controls (1.60 vs. 1.92, P < .001).
No significant difference in RH-PAT was found in female diabetic patients compared to controls.
Diabetic female patients had a greater body mass index compared to diabetic males (24.2 vs. 20.6, P = .003).

Structured PICO

Is endothelial dysfunction present in asymptomatic adolescents with type 1 diabetes compared to healthy controls?

Population

40 adolescents aged 12-16 years, comprising 20 with type 1 diabetes and 20 age- and gender-matched nondiabetic controls. Excluded: smoking, obesity, and hypertension.

Comparator

Age- and gender-matched nondiabetic controls

Outcome

Endothelial dysfunction assessed by reactive hyperemia-peripheral arterial tonometry (RH-PAT)surrogate

Endothelial dysfunction is already present in asymptomatic adolescent males with type 1 diabetes, highlighting a gender-specific early preclinical stage of atherosclerosis.

Cite This Study

Mahmud et al. (2006) studied this question.

synapsesocial.com/papers/6a6f5dc98031ec7bb1dbb699 https://doi.org/10.1111/j.1747-0803.2006.00015.x

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Implication

Endothelial dysfunction may be gender-specific in asymptomatic adolescents with type 1 diabetes; hypothesis-generating and requires prospective confirmation before clinical consideration.

Altered Endothelial Function in Asymptomatic Male Adolescents with Type 1 Diabetes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Altered Endothelial Function in Asymptomatic Male Adolescents with Type 1 Diabetes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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