Why the study?
Is the insertion/deletion polymorphism in the angiotensin-converting enzyme gene associated with essential hypertension in a Gulf Arab population?
Is the insertion/deletion polymorphism in the angiotensin-converting enzyme gene associated with essential hypertension in a Gulf Arab population?
The ACE gene insertion/deletion polymorphism does not play a major role in determining elevated blood pressure in the Gulf Arab population, consistent with findings in other ethnic groups.
ACE I/D testing should not inform essential hypertension care in Gulf Arabs; supports consistent null findings across ethnicities but leaves role open.
We have studied an insertion/deletion dimorphism in the human angiotensin-converting enzyme gene amongst UAE nationals from the Abu Dhabi Emirate. Our findings show lack of association between the I/D allele marker system and clinical diagnosis of essential hypertension, suggesting that variations of the angiotensin-converting enzyme gene do not play a major role in the determination of elevated blood pressure in this Arab population. This agrees with results reported on other ethnic groups.
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Frossard et al. (1997) studied this question.
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