What question did this study set out to answer?

To determine whether an insertion/deletion polymorphism at the ACE locus influences normal systolic and diastolic blood pressure levels or blood pressure variability.

April 1, 1994Clinical Genetics

No effect of insertion/ deletion polymorphism at the ACE locus on normal blood pressure level or variability

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Why the study?

Does the insertion/deletion polymorphism at the ACE locus affect normal blood pressure levels or variability in healthy individuals?

Population

Healthy individuals, comprising three series of unrelated individuals and two series of monozygotic twin…

Comparison

Insertion/deletion polymorphism at the ACE locus vs Different genotypes of the ACE I/D polymorphism

Design

Cross-sectional

Authors

KBKnut Erik BergeGeneral / Preventive / Lipids KBK. BergAarhus University

Discussion

Member takes

Implication

No association with normal BP in healthy adults; leaves open relevance in hypertension or treatment response.

Key Points

To determine whether an insertion/deletion polymorphism at the ACE locus influences normal systolic and diastolic blood pressure levels or blood pressure variability.
Evaluated associations between ACE insertion/deletion genotypes and blood pressure across three series of unrelated individuals (N=140, N=90, and N=136).
Analyzed genotype effects on within-pair blood pressure variation in two series of monozygotic twin pairs (N=130 pairs and N=88 pairs).
No association was observed between insertion/deletion genotypes and systolic or diastolic blood pressure levels across any of the three cohorts of unrelated individuals.
Within-pair variation in systolic and diastolic blood pressure did not differ by genotype in either monozygotic twin cohort, confirming the absence of level gene or variability gene effects.

Structured PICO

Does the insertion/deletion polymorphism at the ACE locus affect normal blood pressure levels or variability in healthy individuals?

Population

Healthy individuals, comprising three series of unrelated individuals (n=140, 90, and 136) and two series of monozygotic twin pairs (n=130 and 88 pairs).

Intervention

Insertion/deletion (I/D) polymorphism at the ACE locus

Comparator

Different genotypes of the ACE I/D polymorphism

Outcome

Level of systolic or diastolic blood pressuresurrogate

The ACE insertion/deletion polymorphism does not appear to influence normal blood pressure levels or variability in healthy individuals.

Cite This Study

Berge et al. (1994) studied this question.

synapsesocial.com/papers/6a7727c64fe2e6ffd8ec741d https://doi.org/10.1111/j.1399-0004.1994.tb04017.x

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No effect of insertion/ deletion polymorphism at the ACE locus on normal blood pressure level or variability

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

No effect of insertion/ deletion polymorphism at the ACE locus on normal blood pressure level or variability

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider