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June 15, 1995Circulation

Angiotensin-Converting Enzyme Gene Polymorphism Has No Influence on the Circulating Renin-Angiotensin-Aldosterone System or Blood Pressure in Normotensive Subjects

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Why the study?

Does the ACE gene I/D polymorphism influence the circulating renin-angiotensin-aldosterone system or blood pressure in normotensive subjects?

Population

24 normotensive male volunteers homozygous for the ACE I/D polymorphism (12 DD and 12 II)

Comparison

Renin inhibitor infusion followed by exogenous… vs Comparison between DD and II genotypes of the…

Design

Cohort

Follow-up

130 minutes

Authors

MLMarie-Laure LachurieInsermMAMichel AziziVascular MedicineTGThan Tam GuyeneInserm

Discussion

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Implication

ACE I/D polymorphism does not alter Ang II generation or BP responses in normotensives; leaves open its relevance in hypertension or disease.

Structured PICO

Does the ACE gene I/D polymorphism influence the circulating renin-angiotensin-aldosterone system or blood pressure in normotensive subjects?

P
Population
24 normotensive male volunteers homozygous for the ACE I/D polymorphism (12 DD and 12 II)
I
Intervention
Renin inhibitor infusion (remikiren 0.1 mg/kg/h for 130 minutes) followed by exogenous Angiotensin I infusion (gradually increased from 1 to 10 ng/kg/min)
C
Comparator
Comparison between DD and II genotypes of the ACE gene
O
Outcome
Effect of the ACE gene I/D polymorphism on blood pressure, plasma active renin, and aldosterone regulationsurrogate

The ACE I/D polymorphism does not limit systemic Angiotensin II generation or its effects on blood pressure and aldosterone in normotensive subjects, despite influencing plasma ACE levels.

Cite This Study

Lachurie et al. (1995) studied this question.

synapsesocial.com/papers/6a6f779a75498292b708dc0ehttps://doi.org/10.1161/01.cir.91.12.2933
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma level and gene polymorphism of angiotensin-converting enzyme in relation to myocardial infarction.1994 · 263 citations
  2. 2Relationships Between Angiotensin I Converting Enzyme Gene Polymorphism, Plasma Levels, and Diabetic Retinal and Renal Complications1994 · 366 citations
  3. 3Different frequencies of angiotensin-converting enzyme genotypes in older hypertensive individuals.1994 · 140 citations
  4. 4Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus.1994 · 231 citations
  5. 5Regional angiotensin II production in essential hypertension and renal artery stenosis.1993 · 104 citations