Analysis of the Complete Genomes of Enterovirus 71 Subtypes in China

Figures

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  Figure 1. The number of EV-A71 isolated strains with the complete genome in different years in China. The height of the histogram represents the number of isolates, and the number on the histogram indicates the number of EV-A71 isolated strains.

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  Figure 2. The number of EV-A71 isolated strains with the complete genome in different provinces of China. The EV-A71 isolated strains with a complete genome cover a total of 22 provinces. Orange represents less than 5 isolates, yellow represents between 5 and 12 isolates, lavender represents between 12 and 30 isolates, and dark purple represents greater than 30 isolates.

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  Figure 3. Phylogenetic tree constructed with the VP1 nucleotide sequences (891 bp) of EV-A71 strains with the complete genome. Red branches indicate genotype C4 strains; blue branches indicate genotype B5 strains; orange branches indicate genotype B1 strains; light blue branches indicate genotype C1 strains; yellow branches indicate genotype C2 strains; pink branches indicate genotype B4 strains; brown branches indicate genotype A strains; purple branches indicate genotype C5 strains. Each strain was named according to the GenBank accession number. Taiwan's strains have a TW suffix, reference strains have corresponding subtype name suffixes, and vaccine strains have the vaccine suffix.

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  Figure 4. Phylogenetic trees constructed with the VP1, VP4, 2C, 3C, 3D, and whole-genome sequences of EV-A71. (a) VP1 phylogenetic tree; (b) VP4 phylogenetic tree; (c) whole genomes phylogenetic tree. The C4 subtree was compressed. Each strain is named according to the GenBank accession number. Taiwan's strains have a TW suffix, and the reference strains have corresponding subtype name suffixes.

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  Figure 5. Phylogenetic trees constructed with 2C, 3C, and 3D of EV-A71. (a) 2C phylogenetic tree; (b) 3C phylogenetic tree; (c) 3D phylogenetic tree. The C4 subtree was compressed. Each strain is named according to the GenBank accession number. Taiwan's strains have a TW suffix, and the reference strains have corresponding subtype name suffixes.