February 6, 2015AJP Renal PhysiologyOpen Access

Renal nerve stimulation leads to the activation of the Na⁺/H⁺exchanger isoform 3 via angiotensin II type I receptor

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Structured PICO

Population

Wistar rats

Intervention

Low-frequency acute electrical stimulation of the renal nerve (ESRN)

Comparator

Losartan-mediated AT1 receptor blockade or unstimulated control

Outcome

NHE3-mediated sodium reabsorption and associated intrarenal renin angiotensin system activation markers (urinary angiotensinogen, renal cortical ANG II, NHE3 activity)surrogate

Low-frequency renal nerve stimulation induces proximal tubular sodium reabsorption via intrarenal renin-angiotensin system activation and AT1 receptor signaling.

Discussion

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Implication

Hypothesis-generating for AT1R-mediated tubular sodium effects; leaves open translation to human cardiorenal disease.

Cite This Study

Filho et al. (2015) studied this question.

synapsesocial.com/papers/6a6f6a45f44fa9f079dcd9ae https://doi.org/10.1152/ajprenal.00515.2014

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