Novel mechanism of intra-renal angiotensin II-induced sodium/proton exchanger 3 expression by losartan in spontaneously hypertensive rats

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Why the study?

Does losartan reduce blood pressure and downregulate the intra-renal Ang II-SGK1-NHE3 pathway in spontaneously hypertensive rats?

Structured PICO

Does losartan reduce blood pressure and downregulate the intra-renal Ang II-SGK1-NHE3 pathway in spontaneously hypertensive rats?

Population

18 rats total: 12 spontaneously hypertensive rats (SHR) and 6 Wistar-kyoto rats (WKY), aged 10 weeks, weighing 150 g.

Intervention

Losartan 30 mg/kg/day by intragastric injection for 8 weeks

Comparator

Saline (same volume) administered to SHR and WKY control groups

Outcome

Changes in blood pressure, Ang II production in plasma and renal tissue, and expression of NHE3 and SGK1 (mRNA and protein)surrogate

Losartan reduces blood pressure in spontaneously hypertensive rats, potentially by downregulating the intra-renal Ang II-SGK1-NHE3 pathway.

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Supports mechanistic research in hypertension models; leaves open translation to clinical practice.

Fan et al. (2014) studied this question.

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