February 7, 2008AJP Cell PhysiologyOpen Access

Intracellular ANG II directly induces in vitro transcription of TGF-β1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT1areceptors

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Why the study?

Does intracellular ANG II directly induce transcription of TGF-beta1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei?

Structured PICO

Does intracellular ANG II directly induce transcription of TGF-beta1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei?

Population

Intact nuclei freshly isolated from the rat renal cortex

Intervention

Angiotensin II (ANG II)

Comparator

Control (absence of ANG II) and AT1 receptor antagonist losartan

Outcome

In vitro transcription of mRNAs for transforming growth factor-beta1, macrophage chemoattractant protein-1, and sodium and hydrogen exchanger-3surrogate

Intracellular ANG II directly stimulates nuclear AT1a receptors to induce transcriptional responses associated with sodium transport, cellular growth, and proinflammatory cytokines independently of cell surface receptor-mediated signaling.

Discussion

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Implication

Hypothesis-generating for nuclear AT1 effects on renal transcription; leaves open in vivo relevance and clinical translation.

Cite This Study

Li et al. (2008) studied this question.

synapsesocial.com/papers/6a6f6a45f44fa9f079dcd9be https://doi.org/10.1152/ajpcell.00432.2007

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Intracellular ANG II directly induces in vitro transcription of TGF-β1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT1areceptors

Structured PICO

Discussion

Implication

Cite This Study

Intracellular ANG II directly induces in vitro transcription of TGF-β1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT1areceptors

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider