Why the study?
Does AT1 receptor knockdown or inhibition reduce ANG II endocytosis and NHE-3 expression in immortalized rabbit proximal tubule cells?
Does AT1 receptor knockdown or inhibition reduce ANG II endocytosis and NHE-3 expression in immortalized rabbit proximal tubule cells?
AT1 receptor-mediated endocytosis of extracellular ANG II regulates proximal tubule sodium transport by increasing total and apical NHE-3 proteins.
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AT1R knockdown may modulate proximal tubule sodium transport; hypothesis-generating for hypertension mechanisms but leaves open in vivo translation.
Li et al. (2007) studied this question.
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