Hematocrit and fibrinogen levels significantly influence middle cerebral artery blood velocity and should be accounted for during transcranial Doppler assessments in elderly patients.
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Hematocrit and fibrinogen may influence TCD velocities in elderly patients; cross-sectional data leave open whether adjustment improves diagnostic accuracy.
We analyzed the association between hematologic factors and blood velocity of the middle cerebral artery in 42 healthy ambulatory subjects aged 63-86 years. We found a significant inverse association between mean velocity and both hematocrit (r = -0.37, p less than 0.02) and fibrinogen concentration (r = -0.42, p less than 0.005). These two variables are independently associated with velocity and together explain 29% of the variance in mean velocity. Both hematocrit and fibrinogen concentration should be considered in the interpretation of transcranial Doppler findings in this population.
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Ameriso et al. (1990) studied this question.
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