Key result
Higher hematocrit is inversely associated with cerebral artery blood flow velocities.
Why the study?
The influence of hematocrit and serum fibrinogen on transcranial Doppler ultrasound measurements of cerebral blood velocities was unclear.
Do hematocrit and serum fibrinogen influence transcranial Doppler measurements of cerebral blood velocities in healthy adults?
Cross-Sectional (n=112)
Do hematocrit and serum fibrinogen influence transcranial Doppler measurements of cerebral blood velocities in healthy adults?
Hematocrit is a strong factor inversely influencing cerebral blood velocities measured by transcranial Doppler ultrasound and should be accounted for in clinical applications.
Answers are grounded in this paper and cite their sources.
Higher hematocrit was associated with lower TCD velocities; leaves open whether adjustment improves diagnostic accuracy in cerebrovascular disease.
To investigate the effect of hematocrit and serum fibrinogen on transcranial Doppler ultrasound (TCD) measurements, we performed, TCD tests and measured hematocrit and serum fibrinogen concentrations in 112 healthy adult volunteers. The mean velocities of the middle cerebral (r = -.37, p < .0001), internal carotid at siphon (r = -.14, p < .05) and cervical level (r = -.14, p < .05), vertebral (r = -.21, p < .005) and the basilar artery (r = -.33, p < .001) were significantly and inversely correlated with hematocrit, while serum fibrinogen weakly affected the mean velocities of the internal carotid artery. The subjects with low hematocrit (< or = 40%) showed significantly higher mean velocities of the middle cerebral, vertebral and basilar arteries than those with high hematocrit (> 40%). Considering the influence of the subject's age and gender, hematocrit is the strongest factor influencing the velocities of the middle cerebral and the basilar artery. These results suggest that hematocrit is an important variable for TCD measurements of the cerebral blood velocities and should be taken into account in TCD application.
No takes yet. Share an insight, caveat, or question.
Sohn et al. (1997) conducted a cross-sectional in Healthy (n=112). Hematocrit and serum fibrinogen was evaluated on Mean velocities of cerebral arteries measured by transcranial Doppler ultrasound (r = -0.37, p=< .0001). Hematocrit was significantly and inversely correlated with mean blood flow velocities in the middle cerebral artery (r = -0.37, p < 0.0001) and other cerebral vessels.
Synapse has enriched 10 related papers. Consider them for comparative context: