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March 1, 1996Journal of Biological ChemistryOpen Access

Prostacyclin and Sodium Nitroprusside Inhibit the Activity of the Platelet Inositol 1,4,5-Trisphosphate Receptor and Promote Its Phosphorylation

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Population

Aspirin-treated platelets and saponin-permeabilized platelets

Comparison

Prostaglandin I2 and sodium nitroprusside vs Control conditions (absence of PGI2/SNP)

Design

Preclinical

Authors

LCLucia CavalliniUniversity of PaduaMCMariagrazia CoassinUniversity of PaduaABAlessio BoreanAULSS 2 Marca Trevigiana

Discussion

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Overview

May advance preclinical platelet research; leaves open human translation or clinical relevance.

Structured PICO

P
Population
Aspirin-treated platelets and saponin-permeabilized platelets
I
Intervention
Prostaglandin I2 (PGI2) and sodium nitroprusside (SNP)
C
Comparator
Control conditions (absence of PGI2/SNP)
O
Outcome
Intracellular calcium concentration ([Ca2+]i) decay and InsP3 receptor phosphorylationsurrogate

PGI2 and SNP inhibit platelet activation by promoting the phosphorylation and inhibition of the InsP3 receptor, thereby enhancing intracellular calcium reuptake.

Cite This Study

Cavallini et al. (1996) studied this question.

synapsesocial.com/papers/6a6f6c01f44fa9f079dcdc1bhttps://doi.org/10.1074/jbc.271.10.5545
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ca2+ influx in platelets: activation by thrombin and by the depletion of the stores. Effect of cyclic nucleotides1994 · 28 citations
  2. 2Calcium Signaling in Human Platelets1990 · 352 citations
  3. 3Prostacyclin inhibits platelet aggregation induced by phorbol ester or Ca2+ ionophore at steps distal to activation of protein kinase C and Ca2+-dependent protein kinases1989 · 46 citations
  4. 4Cyclic AMP-dependent phosphorylation of an immunoaffinity-purified homotetrameric inositol 1,4,5-trisphosphate receptor (type I) increases Ca2+ flux in reconstituted lipid vesicles.1994 · 159 citations
  5. 5Ca<sup>2+</sup> efflux from platelets1994 · 16 citations