July 3, 2012Cardiovascular Research

Intercalated disc abnormalities, reduced Na+ current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes

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Population

Transgenic mice with cardiac overexpression of mutant Desmoglein2 (Dsg2) Dsg2-N271S (Tg-NS/L)

Comparison

Cardiac overexpression of mutant Dsg2-N271S vs Mice with cardiac overexpression of wild-type…

Design

Preclinical

Authors

SRStefania RizzoElectrophysiology ELElisabeth M. LodderAmsterdam Neuroscience AVArie O. VerkerkElectrophysiology

Discussion

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Implication

Suggests early arrhythmogenic mechanisms in ARVC models; extends preclinical insights but leaves open human translation and therapeutic relevance.

Structured PICO

Population

Transgenic mice with cardiac overexpression of mutant Desmoglein2 (Dsg2) Dsg2-N271S (Tg-NS/L)

Intervention

Cardiac overexpression of mutant Dsg2-N271S

Comparator

Mice with cardiac overexpression of wild-type Dsg2 and wild-type mice

Outcome

Intercalated disc remodelling and electrophysiological properties (ventricular activation time, conduction velocities, arrhythmia inducibility, Na+ current density)surrogate

In a mouse model of ARVC, mutant Dsg2 interacts with NaV1.5 and causes reduced Na+ current density and conduction slowing prior to overt structural cardiomyopathic changes.

Cite This Study

Rizzo et al. (2012) studied this question.

synapsesocial.com/papers/6a6f70ea6ceb2bbd16dfa9da https://doi.org/10.1093/cvr/cvs219

Topics

Ventricular arrhythmias

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Implication

Suggests early arrhythmogenic mechanisms in ARVC models; extends preclinical insights but leaves open human translation and therapeutic relevance.

Intercalated disc abnormalities, reduced Na+ current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Intercalated disc abnormalities, reduced Na+ current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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