Population
Guinea-pig ventricular myocytes (inside-out 'macro patches' excised from intact cells)
Design
Preclinical
Authors
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Characterizes Na-Ca exchange kinetics in guinea-pig myocytes; leaves open human translation and clinical relevance.
The study provides detailed kinetic information on the Na+i- and Ca2+i-dependent regulation of native Na+-Ca2+ exchange in guinea-pig ventricular myocytes, showing faster regulation kinetics in macro patches than in other models.
Fujioka et al. (2000) studied this question.
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