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May 1, 1994The Journal of PhysiologyOpen Access

Inactivation of outward Na(+)‐Ca2+ exchange current in guinea‐pig ventricular myocytes.

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Population

Freshly dissociated guinea-pig ventricular myocytes

Design

Preclinical

Authors

SMSatoshi MatsuokaSaitama UniversityDHDonald W. HilgemannElectrophysiology

Discussion

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Implication

Does not alter clinical ion transport management; leaves open the physiological role of Na+-Ca2+ exchanger inactivation in intact hearts.

Structured PICO

P
Population
Freshly dissociated guinea-pig ventricular myocytes
I
Intervention
Manipulation of cytoplasmic and extracellular ion concentrations (Na+, Ca2+, Li+) and intracellular application of chymotrypsin, sodium tetradecylsulphate, or trypsin
O
Outcome
Outward Na(+)-Ca2+ exchange current and its inactivation kineticssurrogate

In intact guinea-pig ventricular myocytes, a significant fraction of Na+-Ca2+ exchangers are in an inactive state, and the mechanism of inactivation appears independent of activation by extracellular monovalent cations.

Cite This Study

Matsuoka et al. (1994) studied this question.

synapsesocial.com/papers/6a22b0ff80ebe3feac149ef8https://doi.org/10.1113/jphysiol.1994.sp020146
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The mechanism by which cytoplasmic protons inhibit the sodium‐calcium exchanger in guinea‐pig heart cells.1993 · 134 citations
  2. 2The effect of exchanger inhibitory peptide (XIP) on sodium-calcium exchange current in guinea pig ventricular cells.1993 · 77 citations
  3. 3Identification of sodium‐calcium exchange current in single ventricular cells of guinea‐pig.1987 · 631 citations
  4. 4Measurement of reversal potential of Na+‐Ca2+ exchange current in single guinea‐pig ventricular cells.1989 · 138 citations
  5. 5Steady-state and dynamic properties of cardiac sodium-calcium exchange. Secondary modulation by cytoplasmic calcium and ATP.1992 · 262 citations