The cardiac Na+-Ca2+ exchanger can generate significant Ca2+ influx upon removal of external Na+ even under conditions of low extracellular Ca2+ and high intracellular Ca2+ buffering.
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NCX can drive Ca2+ influx on Na+ removal despite low external Ca2+; leaves open its role in human Ca2+ dysregulation.
Yoshida et al. (2003) studied this question.
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