What question did this study set out to answer?

Determine how pregestational and gestational maternal diabetes influence the risk of developing specific congenital heart defect phenotypes.

February 15, 2017American Journal of EpidemiologyOpen Access

Original Findings and Updated Meta-Analysis for the Association Between Maternal Diabetes and Risk for Congenital Heart Disease Phenotypes

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Why the study?

Does maternal diabetes increase the risk of specific congenital heart disease phenotypes in offspring?

Population

Deliveries taking place in 1999-2009 from the Texas Birth Defects Registry and statewide vital records

Comparison

Maternal diabetes (pregestational or gestational) vs Nondiabetic women

Design

Meta-analysis

Authors

THThanh T. HoangBaylor College of Medicine LMLisa K. MarengoTexas Department of State Health Services LMLaura E. MitchellThe University of Texas Health Science Center at Houston

Discussion

Member takes

Implication

May inform phenotype-specific CHD screening in diabetic pregnancies; extends group-level associations but leaves open causal inference.

Key Points

Determine how pregestational and gestational maternal diabetes influence the risk of developing specific congenital heart defect phenotypes.
Evaluated birth registry and statewide vital records from 1999 to 2009 (n = 48,249 cases) using multivariable Poisson regression to estimate adjusted prevalence ratios.
Conducted logistic regression with malformed controls to evaluate misclassification bias and synthesized evidence through an updated meta-analysis of pregestational diabetes.
Every congenital heart defect phenotype was significantly elevated in mothers with pregestational diabetes relative to nondiabetic mothers (adjusted prevalence ratios = 2.47–13.20).
Risk associations were present but slightly attenuated among mothers with gestational diabetes across multiple heart defect phenotypes.
Meta-analysis confirmed statistically significant associations between pregestational diabetes and all evaluated congenital heart defect phenotypes.

Structured PICO

Does maternal diabetes increase the risk of specific congenital heart disease phenotypes in offspring?

Population

Deliveries taking place in 1999-2009 from the Texas Birth Defects Registry and statewide vital records (n = 48,249 cases)

Intervention

Maternal diabetes (pregestational or gestational)

Comparator

Nondiabetic women

Outcome

Risk for specific congenital heart disease (CHD) phenotypeshard clinical

Maternal pregestational diabetes is significantly associated with an increased risk for all specific congenital heart disease phenotypes, highlighting the need for targeted counseling.

Cite This Study

Hoang et al. (2017) studied this question.

synapsesocial.com/papers/6a6f77c5febe604dd7086283 https://doi.org/10.1093/aje/kwx033

Topics

Congenital heart disease adults

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Original Findings and Updated Meta-Analysis for the Association Between Maternal Diabetes and Risk for Congenital Heart Disease Phenotypes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Original Findings and Updated Meta-Analysis for the Association Between Maternal Diabetes and Risk for Congenital Heart Disease Phenotypes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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