Key result
Pregestational diabetes is associated with an approximately three times higher risk of congenital heart defects in offspring compared to nondiabetic pregnancies.
Why the study?
The mechanisms governing the association between pregestational diabetes and congenital heart defects, and how maternal diabetes interferes with fetal cardiac development, remain incompletely understood.
Design
Review
Authors
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Supports preconception counseling in diabetes; leaves open prospective validation of phenotype-specific risks.
This review highlights the significant risk of congenital heart defects in offspring of mothers with pregestational diabetes and emphasizes the need to better understand the underlying mechanisms of fetal cardiac maldevelopment.
Maduro et al. (2022) conducted a review in Pregestational diabetes and congenital heart defects. Pregestational diabetes vs. Nondiabetic pregnancies was evaluated on Congenital heart defects in offspring. Pregestational diabetes is associated with an approximately three times higher risk of congenital heart defects in offspring compared to nondiabetic pregnancies.
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