Key result
Pregestational diabetes mellitus increases the risk of fetal congenital heart disease through mechanisms involving elevated oxidative stress, increased apoptosis, and abnormal cardiac neural crest cell migration.
This review highlights the molecular mechanisms underlying the development of congenital heart disease in the context of pregestational diabetes mellitus.
Extends molecular understanding of diabetes-induced congenital heart disease; hypothesis-generating for targets, with no current clinical implications.
Congenital heart disease (CHD) is the most common birth defect at present and has a complex etiology which involves the combined effect of genetic and environmental factors. Pregestational diabetes mellitus is significantly associated with the development of CHD, but the detailed mechanism remains unknown. This article reviews the research advances in the molecular mechanism of CHD caused by pregestational diabetes mellitus.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2017) conducted a review in Congenital heart disease. Pregestational diabetes mellitus vs. Normal pregnancy was evaluated. Pregestational diabetes mellitus increases the risk of fetal congenital heart disease through mechanisms involving elevated oxidative stress, increased apoptosis, and abnormal cardiac neural crest cell migration.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: