Key result
Maternal gestational diabetes mellitus was associated with a significantly higher risk of congenital heart disease in offspring (OR 1.32; 95% CI 1.21 to 1.45; p<0.001).
Why the study?
Maternal diabetes increases congenital heart disease risk in offspring, but studies evaluating the association between gestational diabetes mellitus and congenital heart disease have shown inconsistent results.
Does maternal gestational diabetes mellitus increase the risk of congenital heart disease in offspring?
Comparison
Maternal gestational diabetes mellitus vs without gestational diabetes mellitus
Design
Systematic review and meta-analysis of observational studies
Authors
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Maternal GDM associated with higher offspring CHD risk; confirms link in largest observational meta-analysis but leaves causal inference and screening implications open.
Meta-Analysis (n=46,953,078)
Does maternal gestational diabetes mellitus increase the risk of congenital heart disease in offspring?
Odds Ratio: 1.32 (95% CI 1.21–1.45)
p-value: p=<0.001
Maternal gestational diabetes mellitus is significantly associated with a 32% increased risk of congenital heart disease in offspring.
Liu et al. (2024) conducted a meta-analysis in Congenital Heart Disease (n=46,953,078). Maternal gestational diabetes mellitus vs. No maternal gestational diabetes mellitus was evaluated on Congenital heart disease in offspring (OR 1.32, 95% CI 1.21 to 1.45, p=<0.001). Maternal gestational diabetes mellitus was associated with a significantly higher risk of congenital heart disease in offspring (OR 1.32; 95% CI 1.21 to 1.45; p<0.001).
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