What question did this study set out to answer?

To review how modern high-throughput omics technologies and systems biology methodologies allow comprehensive modeling and quantitative prediction of innate immune responses.

March 21, 2014Annual Review of ImmunologyOpen Access

Systems-Level Analysis of Innate Immunity

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Authors

DZDaniel E. ZakBiogen (United States)VTVincent C. TamTemple University AAAlan AderemSouth African Medical Research Council

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Implication

Review highlights advances in omics-driven modeling of innate immunity, suggesting new predictive frameworks for infectious disease and vaccinology.

Key Points

To review how modern high-throughput omics technologies and systems biology methodologies allow comprehensive modeling and quantitative prediction of innate immune responses.
Synthesized literature on high-throughput measurement platforms (omics) applied to immune cells over time.
Evaluated computational frameworks used to construct predictive molecular and cellular models.
High-throughput measurement technologies enable quantitative mapping of complex gene regulatory networks in immune cells.
Systems-level analyses demonstrate predictive utility in defining influenza pathogenesis and advancing rational vaccine development through systems vaccinology.

Cite This Study

Zak et al. (2014) studied this question.

synapsesocial.com/papers/6a6f7c415d37378ac1dc8b5d https://doi.org/10.1146/annurev-immunol-032713-120254

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Implication

Review highlights advances in omics-driven modeling of innate immunity, suggesting new predictive frameworks for infectious disease and vaccinology.

Systems-Level Analysis of Innate Immunity

Discussion

Member takes

Implication

Key Points

Cite This Study

Systems-Level Analysis of Innate Immunity

Discussion

Member takes

Implication

Key Points

Cite This Study

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