Population
In vitro models studying the human cardiac actin gene promoter, c-fos gene, and interleukin-2 receptor gene
Comparison
Mutation of the CC and GG dinucleotides or… vs Wild-type 'CC.Ar.GG' sequence
Design
Preclinical
Authors
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No immediate clinical implications; extends mechanistic insight into cardiac actin regulation but leaves open in vivo and human relevance.
The 'CC.Ar.GG' box sequence is a critical binding site for nuclear proteins involved in regulating gene expression in response to stimuli such as muscle differentiation and growth stimulation.
Phan-Dinh-Tuy et al. (1988) studied this question.
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