Why the study?
Does pretreatment with PGI2 and theophylline affect shear-induced platelet aggregation and lysis in human platelets?
Population
Human platelets (citrated platelet-rich plasma)
Comparison
Pretreatment with 0.01 microM PGI2 and 500… vs Untreated platelets or platelets treated with…
Design
Preclinical
Follow-up
5 minutes
Authors
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May increase lysis risk at high shear despite lower aggregation; leaves open translation to human platelets.
Does pretreatment with PGI2 and theophylline affect shear-induced platelet aggregation and lysis in human platelets?
While PGI2 and theophylline reduce shear-induced platelet aggregation, they paradoxically increase platelet fragility and lysis at higher shear stress levels, which may have clinical implications for PGI2 use.
Hardwick et al. (1981) studied this question.
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