April 7, 2007Civil War Book Review

TNF-α blockade decreases oxidative stress in the paraventricular nucleus and attenuates sympathoexcitation in heart failure rats

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Why the study?

Does pentoxifylline reduce oxidative stress and sympathoexcitation in a rat model of heart failure?

Structured PICO

Does pentoxifylline reduce oxidative stress and sympathoexcitation in a rat model of heart failure?

Population

Sprague-Dawley rats with congestive heart failure (CHF) induced by coronary artery ligation

Intervention

Pentoxifylline (PTX) for a period of 5 weeks

Comparator

Untreated CHF rats

Outcome

Production of reactive oxygen species (ROS), expression of TNF-alpha and Nox isoforms in the left ventricle and paraventricular nucleus, cardiac function (ejection fraction, Tei index), circulating catecholamines, and renal sympathetic activitysurrogate

TNF-alpha blockade with pentoxifylline attenuates oxidative stress and sympathoexcitation in a rat model of heart failure, highlighting a potential mechanism by which cytokines contribute to CHF pathogenesis.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports TNF-α inhibition in experimental CHF; hypothesis-generating for human translation, requiring clinical trials.

Cite This Study

Guggilam et al. (2007) studied this question.

synapsesocial.com/papers/6a6f85f4ce524a4339c371f2 https://doi.org/10.1152/ajpheart.00286.2007

View Full Paper

Ask AI

Bookmark

TNF-α blockade decreases oxidative stress in the paraventricular nucleus and attenuates sympathoexcitation in heart failure rats

Structured PICO

Discussion

Implication

Cite This Study

TNF-α blockade decreases oxidative stress in the paraventricular nucleus and attenuates sympathoexcitation in heart failure rats

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider