Key result
Pentoxifylline treatment decreased peripheral and central cytokine expression, alleviated nitric oxide dysregulation, and inhibited peroxynitrite formation in the PVN, decreasing sympathoexcitation.
Why the study?
Does pentoxifylline reduce sympathoexcitation in a rat model of heart failure?
Population
Sprague-Dawley rats with heart failure induced by coronary artery ligation
Comparison
Pentoxifylline 30 mg/kg intraperitoneally for 5… vs Vehicle
Design
Preclinical
Follow-up
5 weeks
Authors
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Hypothesis-generating in rat HF; leaves open clinical translation of cytokine modulation.
Does pentoxifylline reduce sympathoexcitation in a rat model of heart failure?
In a rat model of heart failure, cytokine blockade with pentoxifylline attenuated central sympathoexcitation by modulating nitric oxide and angiotensin receptor pathways in the paraventricular nucleus.
Guggilam et al. (2008) studied Heart failure (rat model). Pentoxifylline (PTX) vs. Vehicle was evaluated on Sympathetic outflow, cytokine expression, NOS expression, and peroxynitrite formation in the PVN. Pentoxifylline treatment decreased peripheral and central cytokine expression, alleviated nitric oxide dysregulation, and inhibited peroxynitrite formation in the PVN, decreasing sympathoexcitation.
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