Why the study?
Does overriding drug-drug interaction alerts for QTc-prolonging drugs result in clinically relevant QTc prolongation?
Population
Inpatients with overridden drug-drug interaction alerts on QTc prolongation during a 6-month period…
Comparison
Overriding of drug-drug interaction alerts for… vs Control group using one QTc-prolonging drug
Design
Cohort
Follow-up
1 month
Authors
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Overriding QTc alerts was associated with relevant prolongation; supports ECG monitoring yet leaves optimal strategies open for prospective trials.
Does overriding drug-drug interaction alerts for QTc-prolonging drugs result in clinically relevant QTc prolongation?
Overriding QTc drug-drug interaction alerts frequently leads to clinically relevant QTc prolongation, highlighting the need for routine ECG monitoring in these patients.
Sijs et al. (2008) studied this question.
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