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September 1, 2002Journal of VirologyOpen Access

Isolation of Enzymatically Active Replication Complexes from Feline Calicivirus-Infected Cells

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Population

Feline calicivirus (FCV)-infected cells

Design

Preclinical

Authors

KGKim Y. GreenUniversity of North Carolina at Chapel HillAMAaron MoryPennsylvania State UniversityMFMark H. Fogg3v Geomatics (Canada)

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Implication

Provides an in vitro model for FCV replication; leaves open in vivo validation and broader calicivirus applicability.

Structured PICO

P
Population
Feline calicivirus (FCV)-infected cells
I
Intervention
Isolation of a membranous fraction (FCV replication complexes)
O
Outcome
Synthesis of viral RNA in vitro and identification of associated viral proteinssurrogate

The isolation of enzymatically active replication complexes from FCV-infected cells provides a model to study viral and host contributions to FCV RNA replication.

Cite This Study

Green et al. (2002) studied this question.

synapsesocial.com/papers/6a6f8ffe6ceb2bbd16dfb027https://doi.org/10.1128/jvi.76.17.8582-8595.2002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Detection of the ORF3 polypeptide of feline calicivirus in infected cells and evidence for its expression from a single, functionally bicistronic, subgenomic mRNA1996 · 83 citations
  2. 2Feline Calicivirus Capsid Protein Expression and Capsid Assembly in Cultured Feline Cells1999 · 23 citations
  3. 3Structural and functional characterization of the poliovirus replication complex1992 · 256 citations
  4. 4Cellular origin and ultrastructure of membranes induced during poliovirus infection1996 · 381 citations
  5. 5Identification of poliovirus polypeptide P63 as a soluble RNA-dependent RNA polymerase1980 · 146 citations