Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 1, 2001Journal of VirologyOpen Access

Proteinase-Polymerase Precursor as the Active Form of Feline Calicivirus RNA-Dependent RNA Polymerase

View Full Paper
Ask AI
Bookmark
Share

Population

Feline calicivirus (FCV) RNA-dependent RNA polymerase (RdRP) model

Comparison

Deletion mutations and proteinase inactivation… vs Full-length proteinase-polymerase precursor…

Design

Preclinical

Authors

LWLai WeiSouthwest Jiaotong UniversityJHJason S. HuhnPennsylvania State UniversityAMAaron MoryPennsylvania State University

Discussion

Loading...

Member takes

Implication

Supports FCV RdRp structural studies; leaves open antiviral translation in feline or related calicivirus models.

Structured PICO

P
Population
Feline calicivirus (FCV) RNA-dependent RNA polymerase (RdRP) model
I
Intervention
Deletion mutations and proteinase inactivation of the Pro-Pol precursor protein
C
Comparator
Full-length proteinase-polymerase (Pro-Pol) precursor protein
O
Outcome
Polymerase activitysurrogate

The full-length proteinase-polymerase precursor protein is identified as an active form of the feline calicivirus RNA-dependent RNA polymerase.

Cite This Study

Wei et al. (2001) studied this question.

synapsesocial.com/papers/6a709898e5469ee92be14cb9https://doi.org/10.1128/jvi.75.3.1211-1219.2001
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Purification and characterization of poliovirus polypeptide 3CD, a proteinase and a precursor for RNA polymerase1992 · 121 citations
  2. 2Poliovirus RNA-dependent RNA Polymerase (3Dpol) Is Sufficient for Template Switchingin Vitro1999 · 109 citations
  3. 3Sapporo Virus: History and Recent Findings2000 · 99 citations
  4. 4Protein kinase in HeLa nucleosomes: a reevaluation of the interactions of histones with the ends of core particle DNA1978 · 31 citations