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November 10, 2009Inflammatory Bowel DiseasesOpen Access

Angiopoietin-2 in experimental colitis

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Why the study?

Does Ang-2 deficiency reduce clinical and histopathological features of experimental colitis in mice?

Population

Ang-2(-/-) mice and wild-type (WT) mice with dextran sodium sulfate (DSS)-induced experimental colitis

Comparison

Angiopoietin-2 deficiency (Ang-2(-/-)) vs Wild-type (WT) mice

Design

Preclinical

Authors

VGVijay C. GantaAugusta UniversityWCWalter CromerMitchell InstituteGMGinny L. Mills

Discussion

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Implication

Hypothesis-generating for Ang-2 inhibition in IBD; clinical studies needed before any therapeutic consideration.

Structured PICO

Does Ang-2 deficiency reduce clinical and histopathological features of experimental colitis in mice?

P
Population
Ang-2(-/-) mice and wild-type (WT) mice with dextran sodium sulfate (DSS)-induced experimental colitis
I
Intervention
Angiopoietin-2 deficiency (Ang-2(-/-))
C
Comparator
Wild-type (WT) mice
O
Outcome
Disease activity index, histopathological scoring, leukocyte infiltration, blood and lymphatic vessel density, gut capillary fragility, colon length, and serum protein contentsurrogate

Ang-2 deficiency attenuates inflammatory hemangiogenesis, lymphangiogenesis, and neutrophil infiltration in experimental DSS colitis, suggesting a role for Ang-2 in IBD pathophysiology.

Cite This Study

Ganta et al. (2009) studied this question.

synapsesocial.com/papers/6a6f93d8f44fa9f079dd099fhttps://doi.org/10.1002/ibd.21150
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Also Consider

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