Key result
Patients with inflammatory bowel disease had significantly higher median serum Ang-2 and Tie-2 levels compared with healthy controls (P < 0.05 and P < 0.001, respectively).
Why the study?
Are serum levels of Ang-2 and Tie-2 elevated in patients with inflammatory bowel disease compared to healthy controls?
Case-Control (n=240)
Are serum levels of Ang-2 and Tie-2 elevated in patients with inflammatory bowel disease compared to healthy controls?
p-value: p=<0.05 and <0.001
Serum Ang-2 and Tie-2 levels are elevated in patients with IBD, suggesting a role for angiogenesis and vascular permeability in the disease mucosa.
Elevated Ang-2/Tie-2 levels should not alter IBD management; leaves open angiogenesis as a research target pending prospective validation.
BACKGROUND: Angiogenesis has been suggested to play an important role in inflammatory bowel disease (IBD). The aim of the study was to evaluate the serum markers of angiogenesis angiopoietin-2 (Ang-2) and soluble angiopoietin receptor Tie-2 in patients with ulcerative colitis (UC) and Crohn's disease (CD). MATERIALS AND METHODS: Serum Ang-2 and Tie-2 serum levels were measured in 160 IBD patients (79 UC and 81 CD) and in 80 matched healthy controls using commercially available enzyme-linked immunosorbent assays. Serum Ang-2 and Tie-2 levels were correlated with the disease activity, as well as the type, localization and treatment of the disease. RESULTS: Median serum Ang-2 and Tie-2 levels were significantly higher in both the UC patients and the CD patients compared with the healthy controls (P < 0.05 and P < 0.001, respectively). The IBD patients with early disease (diagnosis < 2 years) had significantly higher (P = 0.04) median serum Ang-2 levels but significantly lower (P = 0.02) median serum Tie-2 levels as compared with IBD patients with late disease (diagnosis > 2 years). The CD patients with active disease had significantly higher levels of Ang-2 compared with non-active disease (P = 0.02). Serum levels of both Ang-2 and Tie-2 were not correlated with laboratory markers such as ESR, CRP, white blood cell count, platelet count and albumin. CONCLUSIONS: Serum Ang-2 and Tie-2 levels are elevated in patients with IBD. These markers may mediate angiogenesis and vascular permeability in the mucosa of patients with IBD.
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Κoutroubakis et al. (2006) conducted a case-control in Inflammatory bowel disease (n=240). Inflammatory bowel disease vs. Healthy controls was evaluated on Serum Ang-2 and Tie-2 levels (p=<0.05 and <0.001). Patients with inflammatory bowel disease had significantly higher median serum Ang-2 and Tie-2 levels compared with healthy controls (P < 0.05 and P < 0.001, respectively).
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