June 14, 2007Anesthesia & Analgesia
The Reliability of Pulse Contour-Derived Cardiac Output During Hemorrhage and After Vasopressor Administration
Why the study?
Does pulse contour-derived cardiac output (PCCO) maintain accuracy compared to reference methods during hemorrhage and vasopressor administration in a porcine model?
Population
13 anesthetized pigs subjected to uncontrolled hemorrhage and subsequent resuscitation with norepinephrine.
Comparison
Pulse contour-derived cardiac output measurement. vs Transpulmonary thermodilution cardiac output and…
Design
Preclinical
Authors
Discussion
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Implication
May not maintain accuracy during hemorrhage or norepinephrine without recalibration in porcine models; leaves open clinical applicability pending human studies.
Structured PICO
Does pulse contour-derived cardiac output (PCCO) maintain accuracy compared to reference methods during hemorrhage and vasopressor administration in a porcine model?
P
Population
13 anesthetized pigs subjected to uncontrolled hemorrhage (via liver incision) and subsequent resuscitation with norepinephrine.
I
Intervention
Pulse contour-derived cardiac output (PCCO) measurement.
C
Comparator
Transpulmonary thermodilution cardiac output (TPCO) and continuous and bolus pulmonary artery cardiac output (CCO and BCO).
O
Outcome
Bias and limits of agreement between CCO and PCCO during hemorrhage and after vasopressor administration.surrogate
Pulse contour-derived cardiac output requires frequent recalibration during conditions of changing hemodynamics, such as hemorrhage and vasopressor administration, to maintain measurement accuracy.
Cite This Study
Bein et al. (2007) studied this question.