Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca 2+ events, and IK Ca channels, reducing arteriolar tone

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Population

Arterioles (preclinical model)

Comparison

Decreasing intraluminal pressure below 50 mmHg vs Arterioles pressurized to 80 mmHg

Design

Preclinical

Authors

Discussion

Supports TRPV4-mediated endothelial Ca2+ signaling in animal vessels; leaves open relevance to human myogenic tone.

Population

Arterioles (preclinical model)

Intervention

Decreasing intraluminal pressure below 50 mmHg (with or without antagonists RN1734, TRAM-34, apamin)

Comparator

Arterioles pressurized to 80 mmHg

Outcome

Endothelial cell Ca2+ event frequency and vasodilation/myogenic tonesurrogate

Low intravascular pressure activates endothelial TRPV4 channels and IKCa channels, leading to vasodilation and reducing myogenic tone.

Bagher et al. (2012) studied this question.

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