Key result
Increases in intraluminal pressure activated K+ channels in rat saphenous arteries, with 10 mM tetraethylammonium suppressing peak whole-cell K+ current by 79%.
Population
Isolated, perfused rat saphenous arteries and patch-clamped vascular muscle cells from the same arteries
Comparison
Stepwise increases in intraluminal pressure and… vs Lower pressures and Ca2+-free solution
Design
Preclinical
Authors
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Hypothesis-generating for myogenic tone in rodent arteries; leaves open translation to human hypertension.
Increases in intraluminal pressure progressively activate tetraethylammonium-sensitive K+ channels in the arterial muscle membrane, serving as a negative feedback mechanism to limit pressure-induced constriction.
Bérczi et al. (1992) studied Normal physiology (rat saphenous artery). Tetraethylammonium and intraluminal pressure increases vs. Baseline or lower pressure (25 mm Hg) was evaluated on Peak whole-cell K+ current suppression and membrane depolarization. Increases in intraluminal pressure activated K+ channels in rat saphenous arteries, with 10 mM tetraethylammonium suppressing peak whole-cell K+ current by 79%.
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