Key result
Pressure-induced membrane depolarization increases Kv1.5 surface abundance and currents in arterial myocytes, limiting vasoconstriction.
Intravascular pressure-induced membrane depolarization selectively increases Kv1.5 surface abundance and currents in arterial myocytes, providing a mechanism to limit vasoconstriction.
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Pressure-induced Kv1.5 trafficking may limit myogenic tone in vitro; leaves open in vivo relevance and any clinical implications.
Kidd et al. (2015) studied this question. Intravascular pressure-induced membrane depolarization vs. Absence of pressure was evaluated on Kv1.5 surface abundance and current density. Intravascular pressure-induced membrane depolarization selectively increased Kv1.5 surface abundance and currents in arterial myocytes, limiting vasoconstriction.
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