Population
Cannulated rat mesenteric small arteries
Comparison
Blockade of calcium-activated K+ channels with… vs Absence of charybdotoxin under similar pressure…
Design
Preclinical
Authors
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KCa channels may mediate myogenic depolarization in rodent arteries; leaves open relevance to human vascular disease.
Blockade of KCa channels with charybdotoxin reduces myogenic responsiveness to pressure elevation in rat mesenteric small arteries, suggesting pressure induces depolarization via closure of KCa channels.
Wesselman et al. (1997) studied this question.
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