Key result
Inhibition of the Na-K pump via reduced extracellular potassium or ouabain substantially increased perfusion pressure in isolated rat hindlimbs, independent of catecholamine release.
Population
Perfused isolated rat hindlimbs from normal and reserpine-treated (catecholamine-depleted) rats
Comparison
Perfusion with solutions containing reduced… vs Perfusion with reference solutions containing…
Design
Preclinical
Authors
Loading...
Hypothesis-generating for vascular tone regulation; leaves open relevance to human physiology or therapy.
Inhibition of the sodium-potassium pump via low extracellular potassium or ouabain increases vascular tone in isolated rat hindlimbs, likely through mechanisms involving intracellular calcium accumulation.
Láng et al. (1980) studied microvascular smooth muscle contraction. Na-K pump inhibition (low K+ or ouabain) vs. 5.9 mM K+ reference solution was evaluated on arterial perfusion pressure. Inhibition of the Na-K pump via reduced extracellular potassium or ouabain substantially increased perfusion pressure in isolated rat hindlimbs, independent of catecholamine release.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: