Key result
Vascular segments from hypertensive rats demonstrated augmented contractile responsiveness to ouabain and potassium-free solution compared to normotensive vessels.
Vascular cells of hypertensive rats demonstrate augmented responsiveness to ouabain and potassium-free solution, suggesting enhanced sodium pump activity.
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Hypothesis-generating for enhanced vascular Na/K-ATPase in hypertension; human studies needed before any clinical translation.
Myers et al. (1987) studied Renal hypertension (2-K, 1C hypertensive rats). Ouabain and potassium-free solution vs. Normotensive vessels was evaluated on Contractile responses (sensitivity and rate of force development). Vascular segments from hypertensive rats demonstrated augmented contractile responsiveness to ouabain and potassium-free solution compared to normotensive vessels.
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