Key result
Ouabain and potassium-free solutions caused both short-term potentiating and long-term depressive effects on the mechanical response of rat mesenteric resistance vessels to norepinephrine.
Ouabain and potassium-free solutions exert both short-term potentiating and long-term depressive effects on the mechanical response of rat mesenteric resistance vessels to norepinephrine.
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May confound vascular reactivity assays in ouabain-treated rat models; leaves open translation to human hypertension or digitalis effects.
Mulvany et al. (1982) studied this question. Ouabain and potassium-free solutions vs. Normal saline solutions was evaluated on Pharmacological and electrophysiological properties (membrane potential and mechanical response). Ouabain and potassium-free solutions caused both short-term potentiating and long-term depressive effects on the mechanical response of rat mesenteric resistance vessels to norepinephrine.
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