Population
Spontaneously hypertensive rats and Wistar-Kyoto rats (6 and 12 weeks old)
Comparison
Ouabain (10(-4) mol/l) added to perfusion medium vs Perfusion medium without ouabain
Design
Preclinical
Authors
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Hypothesis-generating for compensatory sodium-pump changes in mature hypertension models; leaves open human translation and therapeutic relevance.
Mature spontaneously hypertensive rats exhibit increased sodium pump activity in resistance vessels compared to normotensive controls, possibly compensating for increased passive sodium permeability.
Gouthberg et al. (1980) studied this question.
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