What question did this study set out to answer?

To determine whether cellular sodium-potassium pump activity in vascular smooth muscle is depressed in chronic one-kidney perinephritic hypertension.

June 1, 1976Circulation Research

Depressed function of a ouabain-sensitive sodium-potassium pump in blood vessels from renal hypertensive dogs.

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Authors

HOH. W. OverbeckWest Virginia School of Osteopathic Medicine MPM. B. PamnaniUniformed Services University of the Health Sciences TATai AkeraMSD K.K. (Japan)

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Implication

Experimental study demonstrates depressed ouabain-sensitive sodium-potassium pump activity in blood vessels of hypertensive dogs, indicating a cellular mechanism for elevated vascular resistance.

Key Points

To determine whether cellular sodium-potassium pump activity in vascular smooth muscle is depressed in chronic one-kidney perinephritic hypertension.
Excised small mesenteric arteries and splanchnic veins from 12 dogs with chronic one-kidney perinephritic hypertension and 12 normotensive controls.
Sodium-loaded tissues in cold medium and measured the velocity of 86Rb uptake in autologous plasma with and without the pump inhibitor ouabain.
Ouabain-sensitive 86Rb uptake was depressed by 42% in mesenteric arteries (P < 0.05) and by 49% in splanchnic veins (P < 0.01) from hypertensive dogs incubated in autologous plasma.
Ouabain-insensitive 86Rb uptake showed no significant difference between hypertensive and normotensive dogs in either arteries or veins.

Cite This Study

Overbeck et al. (1976) studied this question.

synapsesocial.com/papers/6a712ca435aa2c282ce27d21 https://doi.org/10.1161/01.res.38.6.48

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Implication

Experimental study demonstrates depressed ouabain-sensitive sodium-potassium pump activity in blood vessels of hypertensive dogs, indicating a cellular mechanism for elevated vascular resistance.

Depressed function of a ouabain-sensitive sodium-potassium pump in blood vessels from renal hypertensive dogs.

Discussion

Member takes

Implication

Key Points

Cite This Study

Depressed function of a ouabain-sensitive sodium-potassium pump in blood vessels from renal hypertensive dogs.

Discussion

Member takes

Implication

Key Points

Cite This Study

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