Population
Age-matched (12-week-old) male wild-type and PKG[Cys42Ser]KI mice on a pure C57BL/6j background
Comparison
Intraluminal pressure increases and… vs Wild-type vs PKG[C42S]KI mice; baseline pressure
Design
Preclinical
Authors
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Physiological intraluminal pressure activates PKG via oxidant-induced dimerization, triggering Ca2+ sparks and BK channel activation to buffer myogenic vasoconstriction in resistance arteries.
Physiological intraluminal pressure activates PKG via oxidant-induced dimerization, triggering Ca2+ sparks and BK channel activation to buffer myogenic vasoconstriction in resistance arteries.
Khavandi et al. (2016) studied this question.
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