November 1, 2003AJP Regulatory Integrative and Comparative Physiology

Impaired skeletal muscle perfusion in obese Zucker rats

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Population

Obese Zucker rats (OZR) and lean Zucker rats (LZR)

Comparison

Intravenous infusion of phentolamine, PEG-SOD… vs Untreated OZR and lean Zucker rats (LZR)

Design

Preclinical

Authors

JFJefferson C. FrisbeeOklahoma State University

Discussion

Member takes

Implication

Supports sympathetic and oxidative mechanisms in obese rat perfusion deficits; extends preclinical models but leaves human translation open.

Structured PICO

Population

Obese Zucker rats (OZR) and lean Zucker rats (LZR)

Intervention

Intravenous infusion of phentolamine (10 mg/kg), PEG-SOD (2,000 U/kg), or combined infusion

Comparator

Untreated OZR and lean Zucker rats (LZR)

Outcome

Fatigue of in situ gastrocnemius muscle and active hyperemia during isometric tetanic contractionssurrogate

Altered arteriolar reactivity, reduced microvessel density, and decreased distensibility contribute to impaired skeletal muscle perfusion and performance in obese Zucker rats.

Cite This Study

Jefferson C. Frisbee (2003) studied this question.

synapsesocial.com/papers/6a6f9b9c75498292b708fc77 https://doi.org/10.1152/ajpregu.00239.2003

View Full Paper

Ask AI

Bookmark

Implication

Supports sympathetic and oxidative mechanisms in obese rat perfusion deficits; extends preclinical models but leaves human translation open.

Impaired skeletal muscle perfusion in obese Zucker rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Impaired skeletal muscle perfusion in obese Zucker rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider