October 1, 2001AJP Heart and Circulatory Physiology

Impaired dilation of skeletal muscle microvessels to reduced oxygen tension in diabetic obese Zucker rats

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Population

Isolated skeletal muscle resistance arteries from obese Zucker rats and lean Zucker rats

Comparison

Exposure to hypoxia and various pharmacological… vs Lean Zucker rats (LZR) and untreated vessels

Design

Preclinical

Authors

JFJefferson C. FrisbeeOklahoma State University

Discussion

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Implication

Oxidative stress may impair hypoxic dilation in obese models via PGI2; hypothesis-generating for radical scavengers in human cardiometabolic microvascular disease.

Structured PICO

Population

Isolated skeletal muscle resistance arteries (gracilis arteries) from obese Zucker rats (OZR) and lean Zucker rats (LZR)

Intervention

Exposure to hypoxia and various pharmacological agents including indomethacin, N(omega)-nitro-L-arginine methyl ester, PGH(2)-thromboxane A(2) receptor antagonist, arachidonic acid, iloprost, acetylcholine, sodium nitroprusside, forskolin, aprikalim, and oxidative radical scavengers

Comparator

Lean Zucker rats (LZR) and untreated vessels

Outcome

Hypoxic dilation of isolated skeletal muscle resistance arteriessurrogate

Impaired hypoxic dilation in skeletal muscle microvessels of obese Zucker rats appears to be mediated by superoxide anion scavenging of PGI2, which can be reversed by oxidative radical scavengers.

Cite This Study

Jefferson C. Frisbee (2001) studied this question.

synapsesocial.com/papers/6a8a5a7cf8670bac6e33714a https://doi.org/10.1152/ajpheart.2001.281.4.h1568

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Implication

Oxidative stress may impair hypoxic dilation in obese models via PGI2; hypothesis-generating for radical scavengers in human cardiometabolic microvascular disease.

Impaired dilation of skeletal muscle microvessels to reduced oxygen tension in diabetic obese Zucker rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Impaired dilation of skeletal muscle microvessels to reduced oxygen tension in diabetic obese Zucker rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider