April 1, 2005AJP Regulatory Integrative and Comparative Physiology

Reduced nitric oxide bioavailability contributes to skeletal muscle microvessel rarefaction in the metabolic syndrome

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Why the study?

Does chronic tempol ingestion improve skeletal muscle perfusion and microvessel density in obese Zucker rats?

Population

12-week-old obese Zucker rats (OZR) and lean Zucker rats (LZR)

Comparison

4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl… vs Untreated control conditions

Design

Preclinical

Follow-up

approximately 4 weeks

Authors

JFJefferson C. FrisbeeOklahoma State University

Discussion

Member takes

Implication

No clinical translation yet; extends preclinical evidence for tempol in metabolic syndrome microvascular dysfunction.

Structured PICO

Does chronic tempol ingestion improve skeletal muscle perfusion and microvessel density in obese Zucker rats?

Population

12-week-old obese Zucker rats (OZR) and lean Zucker rats (LZR)

Intervention

4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (tempol) in drinking water for approximately 4 weeks

Comparator

Untreated control conditions

Outcome

Perfusion of in situ gastrocnemius muscle during incremental elevations in metabolic demandsurrogate

Chronic reductions in nitric oxide bioavailability contribute to skeletal muscle microvessel rarefaction and impaired perfusion in a rat model of metabolic syndrome.

Cite This Study

Jefferson C. Frisbee (2005) studied this question.

synapsesocial.com/papers/6a8b8d5d039371f2a38955db https://doi.org/10.1152/ajpregu.00114.2005

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Reduced nitric oxide bioavailability contributes to skeletal muscle microvessel rarefaction in the metabolic syndrome

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Reduced nitric oxide bioavailability contributes to skeletal muscle microvessel rarefaction in the metabolic syndrome

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider