Why the study?
Does a high salt diet induce microvessel rarefaction in rats with reduced renal mass and sham-operated controls?
Population
Rats subjected to a 75% surgical reduction of renal mass (RRM) and normotensive sham-operated control rats
Comparison
High salt (4.0% NaCl) diet for 3 days vs Low salt (0.4% NaCl) diet for 3 days
Design
Preclinical
Follow-up
3 days
Authors
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High-salt diet induces microvessel rarefaction independent of BP in rats; leaves open relevance to human salt sensitivity and microvascular disease.
Does a high salt diet induce microvessel rarefaction in rats with reduced renal mass and sham-operated controls?
A high salt diet rapidly induces microvessel rarefaction and structural alterations in both hypertensive and normotensive rats, independent of blood pressure changes.
Hansen‐Smith et al. (1996) studied this question.
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